研究業績

南　敬

I．欧文原著

  1. Bivalent histone marked gene regulation is vital for VEGF triggered angiogenesis,Kanki Y, Muramatsu M, Miyamura Y, Kikuchi K, Higashijima Y, Suehiro J, Sasaki Y, Kubota Y, Koseki H, Kodama T, Nakao M, Aburatani H, Kurotaki D, and Minami T,  Cell Rep., 2022 Feb 8;38(6):110332. doi:10.1016/j.celrep.2022.110332 
  2. Calcineurin-nuclear factor for activated T cells (NFAT) signaling in pathophysiology of wound healing,Manabe T, Park H, and Minami T, Inflammation and Regeneration, 2021 Aug 18;41(1):26. doi: 10.1186/s41232-021-00176-5
  3. NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator, Muramatsu M, ItoT, Shimoji H, Komiya M, Miyamura Y, Nishiyama K, Suzuki T, and Minami T,Biochem Biophys Res Commun., 2021 Sep 24;571:201-209. doi: 10.1016/j.bbrc.2021.07.072. 
  4. Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background,Muramatsu M, Osawa T, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, Aburatani H, Sakai J, Ryeom S, and Minami T, J Biol Chem., 2021 Jan-Jun 2021;296:100697. doi: 10.1016/j.jbc.2021.100697. 
  5. Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma,Ohguchi H,Park Paul M.C.,wang t,Gryder B E.,Ogiya D,kurata k,zhang x,Li D,pei c,Masuda T,Johansson C,Wimalasena V K,Kim Y,Hino S,Usuki S,Kawano Y,Samur M K,Tai Yu-Tzu,Munshi N C.,Matsuoka M,Ohtsuki S,Nakao M,Minami T,Lauberth S,Khan J,Oppermann U,Durbin A D.,Anderson K C.,Hideshima T,Qi J,Blood Cancer Discovery 2021 Jul;2(4):370-387
  6.  Loss of Down Syndrome Critical Region-1 mediated-hypercholesterolemia accelerates corneal opacity via pathological neovessel formationMasashi Muramatsu*, Suguru Nakagawa*, Tsuyoshi Osawa*, Tetsuya Toyono, Akiyoshi Uemura, Hiroyasu Kidoya, Nobuyuki Takakura, Tomohiko Usui, Sandra Ryeom, Takashi Minami #Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Oct;40(10):2425-2439.DOI: 10.1161/ATVBAHA.120.315003.
  7. Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease. Minami T, Muramatsu M, Kume T. Biol Pharm Bull. 2019;42(10):1609-1619.
  8. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama T. Cell Rep. 2019 Oct 1;29(1):89-103.e7.
  9. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models. Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh JI, Michikawa M, Niida S. PLoS One. 2018 May 8;13(5):e0196929. doi: 10.1371/journal.pone.0196929. eCollection 2018.
  10. SSeCKS/Akap12 suppresses metastatic melanoma lung colonization by attenuating Src-mediated pre-metastatic niche crosstalk. Muramatsu M, Akakura S, Gao L, Peresie J, Balderman B, Gelman IH. Oncotarget. 2018 Sep 11;9(71):33515-33527. doi: 10.18632/oncotarget.26067. eCollection 2018 Sep 11.
  11. Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y. Circ J. 2019 Jan 25;83(2):368-378. doi: 10.1253/circj.CJ-18-0925. Epub 2018 Nov 27.
  12. Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, and Suda T.: Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation. J Bone Miner Res. 2018 33:1785-1798.
  13. Nagai, N., Ohguchi, H., Nakaki, R., Matsumura, Y., Kanki, Y., Sakai, J., Aburatani, H., and Minami, T. *:Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition. PLoS Genet. 2018 14:e1007826.
  14. Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, and OikeY.: Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice. Circ J. 2019 83:368-378.
  15. Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T, Takahashi H, Takano KI, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M, A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS, Sci Rep., 2017, Jun 20;7(1):3855.
  16. Muramatsu M, Gao L, Peresie j, Balderman B, Akakura S, Gelman HI., SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts, Oncotarget, 2017, 8:70281-70298.
  17. Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S.: Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1. PLoS One. 2017 12(4):e0175632
  18. Kanki, Y., Nakaki, R., Shimamura, T., Matsunaga, T., Yamamizu, K., Katayama, S., Suehiro, J.I., Osawa, T., Aburatani, H., Kodama, T., Wada, Y., Yamashita, J.K., and Minami, T.*: Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nuc.Acids.Res. 2017 45: 4344-58
  19. Yamamoto S, Azuma E, Muramatsu M, Hamashima T, Ishii Y, Sasahara M., Significance of extracellular vesicles: pathobiological roles in disease, Cell Struct Funct. 2016, Sep 41(3):126-142.
  20. Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S.: Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1. PLoS One. 2017 12(4):e0175632.
  21. Muramatsu, M. and Minami, T.*: Oncogenic combined calcineurin-NFAT and TLR signals in colon. Trans.Cancer.Res. 2016 5: Supple3
  22. Kanki, Y., Nakaki, R., Shimamura, T., Matsunaga, T., Yamamizu, K., Katayama, S., Suehiro, J.I., Osawa, T., Aburatani, H., Kodama, T., Wada, Y., Yamashita, J.K., and Minami, T.*: Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nuc.Acids.Res. 2017 45: 4344-58
  23. Enomoto, S., Mitsui, K., Kawamura, T., Iwanari, H., Daigo, K., Horiuchi, K., Minami, T., Kodama T., Hamakubo T*. Suppression of Slit2/ROBO1 mediated HUVEC migration by ROBO4. Biochem Biophys Res Commun. 2016 469: 797-80.
  24. Nagai N., and Minami, T*. Emerging role of VEGFC in pathological angiogenesis. eBiomedicine 2015 2: 1588-90.
  25. Suehiro, J.I., Kanki, Y., Makihara, C., Schadler, K., Miura, M., Manabe, Y., Aburatani, H., Kodama, T., and Minami, T.* Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in endothelium. J.Biol.Chem. 2014 289:29044-59.
  26. He, B., Lanz, R.B., Fiskus, W., Geng, C., Yi, P., Hartig, S.M., Rajapakshe, K., Shou, J., Wei, L., Shah, S.S., Foley, C., Chew, S.A., Eedunuri, V.K., Bedoya, D.J., Feng, Q., Minami, T., Mitsiades, C.S., Frolov, A., Weigel, N.L., Hilsenbeck, S.G., Rosen, D.G., Palzkill, T., Ittmann, M.M., Song, Y., Coarfa, C., O'Malley, B.W., and Mitsiades N. *: GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 111:18261-6.
  27. Arita, Y., Nakaoka, Y., Matsunaga, T., Kidoya, H., Yamamizu, K., Arima, Y., Kataoka-Hashimoto, T., Ikeoka, K., Yasui ,T., Masaki, T., Yamamoto, K., Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami, T., Yamauchi-Takihara, K., Koh, G.Y., Mochizuki, N., Takakura, N., Sakata, Y., Yamashita, J.K., and Komuro, I.*. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart Nat. Commun. 2014 5: 4552
  28. Daigo, K, Nakakido, M, Ohashi, R, Fukuda, R, Matsubara, K, Minami, T., Yamaguchi, N, Inoue, K, Jiang, SY, Naito, M, Tsumoto, K, and Hamakubo, T* Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis. Sci signal 2014 7:343 ra88
  29. Tanaka, T., Tahara-Hanaoka, S., Nabekura, T., Ikeda, K., Jiang, S., Tsutsumi, S., Inagaki, T., Magoori. K., Higurashi, T., Takahashi, H., Tachibana, K., Tsurutani, Y, Raza, S., Anai, M., Minami, T., Wada, Y., Yokote ,K., Doi, T., Hamakubo, T., Auwerx, J., Gonzalez, F.J., Nakajima, A., Aburatani, H., Naito, M., Shibuya, A., Kodama, T., and Sakai, J.*. PPARβ/δ activation of CD300a controls intestinal immunity. Sci. Rep. 2014 4: 5412
  30. Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, and Oike Y*.: Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Arterioscler Thromb Vasc Biol. 2014 34:790-800.
  31. Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells Plos One 2014 9: e96005
  32. Minami T, Jiang S, Schadler K, Suehiro JI, Osawa T, Oike Y, Miura M, Naito M, Kodama T, and Ryeom S: The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases. Cell Rep. 2013 4: 709-23.
  33. Méndez-Barbero, N., Esteban,V., Escolano,A., Urso, K., Rodríguez, C., Osawa, T., Andrés, V., Martínez-González, J., Minami, T., Redondo, J.M. and Campanero, M.R: A major role for RCAN1 in atherosclerosis progression. EMBO. Mol.Med. 2013 5: 1-17.
  34. Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, and Shibuya M.: BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene 2014 33: 3803-11.
  35. Osawa, T., Tsuchida, R., Muramatsu, M., Shimamura, T., Wang, F., Suehiro, J., Kanki, Y., Wada, Y., Yuasa,Y., Aburatani, H., Miyano, S,. Minami, T., Kodama, T., and Shibuya, M.: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Res. 2013 73: 3019-28.
  36. Yamazaki, T., Suehiro, J-I., Miyazaki, H., Minami, T., Kodama, T., Miyazono, K., and Watabe, T.: The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII. Biochem J. 2013 452: 345-57.
  37. Higuchi, K., Nakaoka, Y., Shioyama, W., Arita, Y., Hashimoto, T., Yasui, T., Ikeoka, K., Kuroda, T., Minami, T., Nishida, K., Fujio, Y., Yamauchi-Takihara, K., Shirai, M., Mochizuki, N., and Komuro, I.: Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation and Atherosclerosis in Apolipoprotein E Knockout Mice. Circ J. 2012 76: 2031-40.
  38. Yae, T., Tsuchihashi, K., Ishimoto, T., Motohara, T., Yoshikawa, M., Yoshida, G.J., Wada, T., Masuko, T., Mogushi, K., Tanaka, H., Osawa, T., Kanki, Y., Minami, T., Aburatani, H., Ohmura, M., Kubo, A., Suematsu, M., Takahashi, K., Saya, H., and Nagano, O.: Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat. Commun., 2012 3: 883.
  39. Endo, M., Nakano, M., Kadomatsu, T., Fukuhara, S., Kuroda, H., Mikami, S., Hato, T., Aoi, J., Tabata, M., Horiguchi, H., Kawamoto, Y., Miyata, K., Odagiri, H., Miyashita, K., Araki, K., Harada, M., Horio, H., Hishima, T., Nomori, H., Ito, T., Yamamoto, Y., Minami, T., Okada, S., Takahashi, T., Iwase, H., Mochizuki, N., and Oike, Y.: A critical role for tumor cell-derived Angiopoietin-like protein 2 in metastasis. Cancer Res. 2012 72:1784-1794.
  40. Sobrado, M., Ramirez, B.G., Neria, F., Lizasoaín, I., Arbonés, M.L., Minami, T., Redondo, J.M., Moro, M.A., and Cano, E.: Regulator of Calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury. Journal of Neuroinflammation 2012 9: 48.
  41. Osawa, T., Muramatsu, M., Wang, F., Tsuchida, R., Kodama, T., Minami, T., and Shibuya, M.: Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011 108: 20725-9.
  42. Kanki, Y., Kohro, T., Jiang, S. Tsutsumi, S., Mimura, I., Suehiro, J.I., Wada, Y., Ohta, Y., Ihara, S., Iwanari, H., Naito, M., Hamakubo, T., Aburatani, H., Kodama, T., and Minami, T.: Epigenetically coordinated GATA2 binding is necessary for endothelium specific endomucin expression EMBO. J. 2011 30: 2582-95.
  43. Tozawa, H., Kanki, Y., Suehiro, J.I., Tsutsumi, S., Kohro, T., Aburatani ,H., Aird, W.C., Kodama, T., and Minami, T.: Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter. Mol Cell Biol. 2011 31: 2196-209.
  44. Yoshimatsu, Y., Yamazaki, T., Mihira, H., Itoh, T., Suehiro, J., Yuki, K., Harada, K., Morikawa, M., Iwata, C., Minami, T., Morishita, Y., Kodama, T., Miyazono, K., and Watabe, T.: Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J. Cell. Sci.2011 124: 2753-62.
  45. Shioyama, W., Nakaoka, Y., Higuchi, K., Minami, T., Taniyama, Y., Nishida, K., Kidoya, H., Sonobe, T., Naito, H., Arita, Y., Hashimoto, T., Kuroda, T., Fujio, Y., Shirai, M., Takakura, N., Morishita, R., Yamauchi-Takihara, K., Kodama, T., Hirano, T., Mochizuki, N., and Komuro, I.: Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling. Circ. Res. 2011 108: 664-75.
  46. Liu, J., Yuan, L., Molema, G., Regan, E., Janes, L., Beeler, D., Spokes, K.C., Okada, Y., Minami, T., Oettgen, P., and Aird, W.C.: Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood 2011 117:342-51.
  47. Omori, Y., Katoh, K., Sato, S., Muranishi, Y., Chaya, T., Onishi, A., Minami, T., Fujikado, T., and Furukawa, T.: Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina. PLoS One. 2011 6: e19685.
  48. Nagahama, Y., Ueno, M., Miyamoto, S., Morii, E., Minami, T., Mochizuki, N., Saya, H., and Takakura, N.: PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties. Cancer. Res. 2010 70: 1215-24.
  49. Suehiro, J., Hamakubo, T., Kodama, T., Aird, W.C., and Minami, T.: Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood 2010 115: 2520-32.
  50. Minami, T., Yano, K., Miura, M., Kobayashi, M., Suehiro, J-I., Reid, P.C., Hamakubo, T., Ryeom, S., Aird, W.C. and Kodama T.: The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J. Clin. Invest. 2009 119; 2257-70.
  51. Baek, K.H., Zaslavsky, A., Lynch, R.C., Britt, C., Okada, Y., Siarey, R.J., Lensch, M.W., Park, I.H., Yoon, S.S., Minami, T., Korenberg, J.R., Folkman, J., Daley, G.Q., Aird, W.C., Galdzicki, Z., and Ryeom, S.: Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009 459; 1126-30.
  52. Song, H., Suehiro, J.I., Kanki, Y., Kawai, Y., Inoue, K., Daida, H., Yano, K., Ohashi, T., Ottegen, P., Aird, W.C., Kodama, T., and Minami, T.: A critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 2009 284:29109-29124.
  53. Hata K, Watanabe Y, Nakai H, Minami T, Ohsaki H, Hirakawa E, Hoshiai H.: Association of metastin/a G-protein-coupled receptor signaling and Down syndrome critical region 1 in epithelial ovarian cancer. Anticancer Res. 2009 29: 617-23.
  54. Kyttälä S, Habermann I, Minami T, Ehninger G, and Kiani A.: Regulation of Down Syndrome Critical Region 1 expression by Nuclear Factor of Activated T cells in megakaryocytes. Brit. J. Haematol. 2009 144: 395-408.
  55. Jin, E., Liu, J., Suehiro, J.I., Yuan, L., Okada, Y., Nikolova-Krstevski, V., Yano, K., Janes, L., Beeler, D., Spokes, K.C., Li, D., Regan, E., Shih, S.C., Oettgen, P., Minami, T., and Aird, W.C.: Differential roles for ETS, CREB and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood. 2009 114:5557-66.
  56. Liu, J., Kanki, Y., Okada, Y., Jin, E., Yano, K., Shih, S.C., Minami, T., and Aird, W.C.: A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J. Thromb. Haemost. 2009 7:1384-92.
  57. Wada, Y., Ohta, Y., Xu, M,. Tsutsumi, S., Minami, T., Inoue, K., Komura, D., Kitakami, J., Oshida, N., Papantonis, A., Izumi, A., Kobayashi, M., Meguro, H., Kanki, Y., Mimura, I., Yamamoto, K., Mataki, C., Hamakubo, T., Shirahige, K., Aburatani, H., Kimura, H., Kodama, T., Cook, P.R., and Ihara, S.: A wave of nascent transcription on activated human genes. Proc. Natl. Acad. Sci. U S A. 2009 106:18357-61.
  58. Sako, K., Fukuhara, S., Minami, T., Hamakubo, T., Song, H., Kodama, T., Fukamizu, A., Gutkind, J.S., Koh, G.Y., and Mochizuki, N.: Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J. Biol. Chem. 2009 284: 5592-601.
  59. Kanamoto, T., Mizuhashi, K., Terada, K., Minami, T., Yoshikawa, H., and Furukawa, T.: Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev. Biol. 2009 9:70.
  60. Canellada, A., Ramirez, B.G., Minami, T., Redondo, J.M., and Cano, E.: Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes. Glia 2008 56: 709-22.
  61. Abid, M.R., Nadeau, R.J., Spokes, K.C., Minami, T., Li, D., Shih, S.C., and Aird, W.C.: Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2008 28:2042-8.
  62. Okada, Y., Jin, E., Nikolova-Krstevski, V., Yano, K., Liu, J., Beeler, D., Spokes, K., Kitayama, M., Funahashi, N., Doi, T., Janes, L., Minami, T., Oettgen, P., and Aird, W.C.: A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood 2008 112: 2336-9.
  63. Fukuhara, S., Sako, K., Minami, T., Noda, K., Kim, HZ., Kodama, T., Shibuya, M., Takakura, N., Koh, G.Y., and Mochizuki, N.: Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nature Cell Biol. 2008 10: 513-26.
  64. Kawai, Y., Hosaka, K., Kaidoh, M., Minami, T., Kodama, T., and Ohhashi, T.: Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Lymphat. Res. Biol. 2008 6: 15-27.
  65. akaoka, Y., Nishida, K., Narimatsu, M., Kamiya, A., Minami, T., Sawa, H., Okawa, K., Fuji, Y., Koyama, T., Maeda, M., Sone, M., Yamasaki, S., Arai, Y., Koh, G.Y., Kodama, T., Hirota, H., Otsu, K., Hirano, T., and Mochizuki, N. : Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J. Clin. Invest. 2007 117: 1771-81.
  66. Kawai, Y., Minami, T., Fujimori, M., Hosaka, K., Mizuno, R., Ikomi, F., Kodama, T. and Ohhashi, T.: Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Lymph. Res. Biol. 2007 5: 115-26.
  67. Okada, Y., Yano, K., Jin, E., Funahashi, N., Kitayama, M., Doi, T., Spokes, K., Beeler, D. L., Shih, S. C., Okada, H., Danilov, T. A., Maynard, E., Minami, T., Oettgen, P., and Aird, W. C.: A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. Circ. Res. 2007 100: 1712-22.
  68. Warabi, N., Takabe, W., Minami, T., Inoue, K., Itoh, K., Yamamoto, M., Ishii, T., Kodama, T., and Noguchi, N. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species. Free Radic. Biol. Med. 2007 42: 260-9.
  69. Inoue, K., Kobayashi, M., Yano, K., Miura, M., Izumi, A., Mataki, C., Doi, T., Hamakubo, T., Reid, P.C., Hume, D.A., Yoshida, M., Aird, W.C., Kodama, T., and Minami, T.: Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression. Arterioscler. Thromb. Vasc. Biol. 2006 26: 2652-9.
  70. ○Horiuchi, K., ○Umetani, M., ○Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, P.C., Housman, D.E., Hamakubo, T., and Kodama, T.: Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc. Natl. Am. Sci. 2006 103: 17278-83. ○ contributed equally
  71. Abid, M.R., Shih, S.C., Out, H.H., Spokes, K.C., Okada, Y., Curiel, D.T., Minami, T., and Aird, W.C. A novel class of vegf-responsive genes that require forkhead activity for expression. J. Biol. Chem. 2006 281: 35544-53.
  72. Minami, T., Miura, M., Aird, W.C., and Kodama, T.: Thrombin-induced auto-inhibitory factor, down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in endothelium. J. Biol. Chem. 2006 281: 20503-20.
  73. Wada, Y., Otu, H., Abid, M.R., Okada, H., Libermann, T., Kodama, T., Shih, S.C., Minami, T., and Aird, W.C. Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. FASEB J. 2005 19: 1914-6.
  74. Cano, E., Canellada, A., Minami, T., Iglesias, T., and Redondo, J.M. Depolarization of neural cells induces transcription of the Down sundrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway. J. Biol. Chem. 2005 280: 29435-43.
  75. Kobayashi, M., Inoue, K., Warabi, E., Minami, T., Kodama, T. A simple method of isolating mouse aortic endothelial cells. J. Arterio. Thromb. 2005 12: 138-42.
  76. Minami, T., Horiuchi, K., Miura, M., Abid, R., Takabe, W., Kohro, T., Ge, X., Aburatani, H., Hamakubo, T., Kodama, T., and Aird, W.C.: Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J. Biol. Chem. 2004 279: 50537-54. (selected the paper of the week).
  77. Minami, T., Murakami, T., Horiuchi, K., Miura, M., Noguchi, T., Miyazaki, J.I., Hamakubo, T., Aird, W.C., and Kodama,T.: Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J. Biol. Chem. 2004 279: 20626-35.
  78. Abid, M.R., Guo, S., Minami, T., Spokes, K.C., Ueki, K., Skurk, C., Walsh, K., and Aird, W.C.: Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2004 24: 294-300.
  79. Minami, T., Kuivenhoven, J. A., Evans, V., Kodama, T., Rosenberg, R.D., and Aird, W.C. Ets Motifs are Necessary for Endothelial Cell Specific Expression of a 723-bp Tie-2 Promoter/Enhancer in Hprt-Targeted Transgenic Mice. Arterioscler. Thromb. Vasc. Biol. 2003 23: 2041-7.
  80. Okada, Y., Nagai, R., Sato, T., Matsuura, E., Minami, T., Morita, I., and Doi ,T.: Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. Blood 2003 101: 4748-56.
  81. Minami, T., Abid, M.R., Zhang, J., King, G., Kodama, T., and Aird, W.C. : Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J. Biol. Chem. 2003 278: 6976-6984.
  82. Matsui, Y., Saiura, A., Sugawara, Y., Sata, M., Naruse, K., Yagita, H., Kohro, T., Mataki, C., Izumi, A., Yamaguchi, T., Minami, T., Sakihama, T., Ihara, S., Aburatani, H., Hamakubo, T., Kodama, T., and Makuuchi, M.: Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade. Physiol. Genomics 2003 15: 199-208.
  83. Minami, T., Donovan, D.J., Tsai, C., Rosenberg, R.D., and Aird, W.C. : Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood 2002 100: 4019-25.
  84. Wu, S-Q., Minami, T., Donovan, D.J., and Aird, W.C.: The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood 2002 100: 4454-61.
  85. Minami, T., and Aird, W.C.: Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J. Biol. Chem. 2001 276: 47632-41.
  86. Tsai, C., Zhang, J., Minami, T., Voland, C., Zhao, S., Yi, X., Lassalle. P., Oettgen, P. and Aird, W.C.: Cloning and characterization of the human lung endothelial cell-specific molecule-1 promoter. J. Vasc. Res. 2001 39: 148-59.
  87. Obika, S., Uneda, T., Sugimoto, T., Nanbu, D., Minami, T., Doi, T. and Imanishi, T.: 2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties. Bioorg. Med. Chem. 2001 9: 1001-11.
  88. Minami, T., Rosenberg, R.D., and Aird, W.C.: Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site. J. Biol. Chem. 2000 276: 5395-5402.
  89. Obika, S., Yu, W., Shimoyama, A., Uneda, T., Minami, T., Miyashita, K., Doi, T. and Imanishi, T.: Properties of cationic liposomes composed of cationic lipid YKS-220 having an ester linkage: adequate stability, high transfection efficiency, and low cytotoxicity. Biol. Pharm. Bull. 1999 22: 187-90.
  90. Minami, T., Tachibana, K., Imanishi, T and Doi, T.: Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression. Eur. J. Biochem. 1998 258: 879-889.
  91. Doi, T., Minami, T., Itoh, M., Aburatani, H., Kodama, T., Kondo, N., Satoh, Y., Asayama, T. and Imanishi, T.: An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. Biochem. Biophys. Res. Commun. 1997 235: 625-630.
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